What is the most efficient way to Python remove from list based on different scenarios?

Been working with Python for nearly a decade now, and when it comes to small, straightforward deletions—like removing a handful of known values—I keep it simple. I use .remove() but always guard it to avoid those annoying ValueErrors.

for item in items_to_remove:
    if item in my_list:
        my_list.remove(item)

It’s a clean, readable way to handle removals safely. Just a heads-up—.remove() only knocks out the first occurrence, so if you’re dealing with duplicates, you’ll need a loop or a list comprehension. For me, this method is my go-to when dealing with just a few values. It’s the classic start point when thinking about python remove from list strategies.